How is our brain changed by the space we work in? What does that space do to make us thrive? These are questions that animate Sandi Chapman, Ph.D., the founding director of the Center for Brain Health (part of the University of Texas at Dallas). Her inquiries are not just academic; at the Center’s new Brain Performance Institute—where clinicians and therapists work to improve brain function in healthy people through preventive care, and treat brain-based conditions and disorders including dementia, PTSD, and ADHD—she has translated the ideas generated by these queries into the three dimensions of building.