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Everything inside Downtown—a buzzing hotel, hostel, restaurant, and retail complex in the center of Mexico City —has a story.

For the Renaissance Barcelona Fira Hotel, sited near a convention center on the highway to the city's airport, Jean Nouvel took on the challenge of making meaningful architecture out of what Rem Koolhaas famously defined as “junkspace“—the anonymous, generic sprawl that rings cities everywhere.

Neri&Hu finds a number of innovative ways to reinterpret old China for the 21st century.

Rene Gonzalez's new Alchemist shop on Miami's Lincoln Road has some tough competition. It stands on a popular plaza opposite a garish movie theater, the Regal South Beach.

Bookstores may be closing right and left in cities all over the world, but in January 2012 Tokyo welcomed Daikanyama Tsutaya Books with an enthusiastic embrace.

Behind the eye-catching design of the 969,000-square-foot Rey Juan Carlos Hospital in the Madrid suburb of M'stoles, Spanish architect Rafael de La-Hoz has created a therapeutic atmosphere, organizing the building around accessible atria that help orient patients and immerse them in a protective, inward-looking environment.

Last fall, the artist Tatzu Nishi created a fully furnished living room around the statue at the center of New York's Columbus Circle.